In vitro and in vivo cooperative suppression of the growth of klebsiella pneumoniae by antibiotics and leukocytes

Abstract

In vitro and in vivo effects of leukocytes on suppression of the growth of Klebsiella pneumoniae treated with gentamicin, cefodizime and ceftazidime were investigated. When bacteria pretreated with 4 MICs of each antibiotic were incubated with leukocytes, growth of the bacteria was suppressed more than in the absence of pretreatment. Bacterial growth in a mouse sepsis model was more suppressed in normal and G-CSF treated mice than in X-ray irradiated mice administered of each of the antibiotics. These results confirm that not only gentamicin but cefodizime and ceftazidime have suppressive effects on bacterial growth as a result of cooperative activity with host defense mechanisms. © 1994, Japanese Society of Chemotherapy. All rights reserved.