Effect of inhaled corticosteroids on bone mineral density in patients with asthma

Abstract

Background: Inhaled corticosteroids (ICS) are a safe treatment for asthma. However, at higher doses, ICS use has been reported to inhibit adrenocortical function. Objective: This study aimed to evaluate the effect of ICS on bone mineral density (BMD) in adult patients with asthma. Methods: Ultrasonic bone densitometry was performed in 40 patients (14 men, 26 women, mean age 61.2 years, mean duration of asthma 6.19 years) who were receiving ICS for asthma, and the whole bone density, thickness of cortical bone, and density of cancellous bone of the radius was measured. The age-matched mean was set as 100%. Lifetime cumulative dose of ICS was calculated using all past prescriptions. Results: No significant correlations were observed between lifetime cumulative ICS dose and whole bone density (r2 = 0.011), cortical bone thickness (r2 = 0.022), and cancellous bone density (r2 = 0.004). No significant differences were observed between lower and higher lifetime cumulative ICS dose among these BMD parameters (104% vs 97%, 103% vs 99%, and 106% vs 91%, respectively). No significant correlations or differences in lifetime cumulative ICS dose were observed by asthma severity, asthma duration, and pulmonary function. Also, serum markers of bone metabolism showed no significant correlations or differences with lifetime cumulative ICS dose. Conclusions: In the entire study population, long-term ICS use was safe and was not associated with an increased risk of osteoporosis.