0619 Patients With Developmental Disorders (adhd And Asd) Accompany With Hypersomnolence Have Normal Orexin Levels.

Abstract

Introduction: In recent times, attention has been paid to the relationship between developmental disorders such as attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), and sleep disorders. Previously, we had been focus on the problems of nocturnal sleep, such as insomnia and circadian rhythm disorder in ASD patients. Recently, we meet many developmental disorder patients who complaint hypersomnolence. Among these patients, they diagnosed as central hypersomnia alone are decreased. While cases with coexistence of central hypersomnia and developmental disorders, or developmental disorder alone are increased. To investigate orexin levels of these patients, we have been measuring for CSF orexin in 18 cases suspected both hypersomnolence and developmental disorders. Methods: We have been measuring for CSF orexin in 16 cases suspected both hypersomnolence and developmental disorders. Among them, 6 were from our clinic and 10 were received samples from other hospitals. In order to diagnose hypersomnolence disorders, PSG and MSLT were performed. In addition, for diagnosis developmental disorders, WAIS-III, WISC-IV, CAARS (Conners' Adult ADHD Rating Scales), AQ (The Autism-Spectrum Quotient) were performed. Results: In 16 examined hypersomnolence cases, 10 cases coexisted ADHD and 4 cases coexisted ASD. Two cases diagnosed as both ADHD and ASD. In 10 ADHD cases, 3 cases had low orexin levels (<110pg/ml), and 7 cases had normal orexin levels (>200pg/ml). In 4 ASD cases, all cases had normal orexin levels. Two cases with ADHD and ASD had normal orexin levels. 6 out of 18 cases were not diagnosed as central hypersomnia. These 6 cases were categorized as 4 ADHD and 2 ASD. Conclusion: It was not reported whether the orexin levels are low or normal in ADHD and ASD patients. In current study, our majority cases were normal orexin levels. Our 3 cases who had low orexin levels were considered to have ADHD symptoms secondarily. Therefore, we thought that the orexin levels were normal in ADHD and ASD patients. Other neurotransmitters, such as oxytocin for ASD and neurotensin for ADHD, should be measured in the future.