Heterogeneity poses a challenge to linkage mapping. Here, we apply a latent class extension of Haseman-Elston regression to expression phenotypes with significant evidence of linkage to trans regulators in 14 large pedigrees. We test for linkage, accounting for heterogeneity, and classify individual families as "linked" and "unlinked" on the basis of their contribution to the overall evidence of linkage.
CITATION STYLE
Bastone, L. A., Putt, M. E., Ten Have, T. R., Cheung, V. G., & Spielman, R. S. (2007). Genetic heterogeneity and trans regulators of gene expression. BMC Proceedings, 1(S1). https://doi.org/10.1186/1753-6561-1-s1-s80
Mendeley helps you to discover research relevant for your work.