Model studies in recognition using new molecular shapes

Abstract

The challenges presented by the selective complexation of small, biologically significant molecules are being faced through the use of new molecular shapes in which stereoelectronic considerations are incorporated. Molecular clefts, in which hydrogen bond donors and acceptors are arranged in a convergent sense, are particularly advantageous for this purpose. They are readily assembled and their linings can be altered to provide microenvironments complementary to a range of target structures. Amines, metal ions, nucleic acid components, and amino acids have all been bound within such structures. In addition, applications in biomimetic catalysis and asymmetric recognition are being developed. © 1989 IUPAC