Polyethyleneglycol an efficient solvent for stereoselective synthesis of ß-amino ketones via direct Mannich reaction

Abstract

Polyethyleneglycol- 2,4,6-Trichloro-1,3,5-Triazine (PEG 400-TCT) promotes a series of three component one-pot reactions of cyclohexanones with aromatic aldehydes and aniline, ß-amino ketones are afforded in high yields and high stereoselectivity, in favor of the anti-isomer. Four new compounds are reported. © ARKAT USA, Inc.