Gene-set enrichment analysis and visualization on the web using EnrichmentMap:RNASeq

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Abstract

EnrichmentMap: RNASeq (enrichmentmap.org) is an intuitive, web-based app for gene-set enrichment analysis and visualization, specifically supporting two-case RNA-Seq experiments for Homo sapiens. The web app introduces a simplified user interface, faster processing times, and eliminates the need for software installation compared to running similar workflows in the Cytoscape desktop software, catering to biologists with minimal computational experience. EnrichmentMap: RNASeq is a new type of Cytoscape web app that is interoperable with Cytoscape. Availability and implementation The app is available to use at enrichmentmap.org and the source code is available at github.com/cytoscape/enrichment-map-webapp.

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Franz, M., Lopes, C. T., Kucera, M., Voisin, V., Isserlin, R., & Bader, G. D. (2025). Gene-set enrichment analysis and visualization on the web using EnrichmentMap:RNASeq. Bioinformatics Advances, 5(1). https://doi.org/10.1093/bioadv/vbaf178

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