Antioxidant, antimicrobial and anti-inflammatory activities development of methanol extract of Cyclamen africanum B. et R., growth in Jijel - Algeria

Abstract

The genus Cyclamen L. (Primulaceae) is represented by 20 species, where inter alia Cyclamen africanum B. et R, is the only endemic species presented in Algeria. The study of their biological potentialities was evaluated through antioxidant, antimicrobial and anti-inflammatory activities. The antioxidant activity was evaluated by DPPH and the reducing power essay, the antimicrobial activity was tested with three bacterial strains and one yeast (Staphylococcus aureus ATCC25923, Klebsiella pneumonia ATCC700603, Bacillus subtilis ATCC6633 and Candida albicans ATCC1024) and anti-inflammatory activity with the Human Red Blood Cell (HRBC) membrane stabilization method. The results demonstrate a perfect antioxidant activity and an excellent anti- inflammatory power at very small concentrations. Keywords: Cyclamen; crude extract; reducing power; antimicrobial; HRBC.