Química combinatória: moderna ferramenta para a obtenção de candidatos a protótipos de novos fármacos

Abstract

Nowadays, Combinatorial Chemistry is one of the most promising tools used in the design and discovery of new molecules potentially useful in the therapeutics. In this methodology, the reaction products are synthesized simultaneously and can be evaluated once, either in a complex mixture or as isolated compounds. The main aim of this new approach is the time for the development of new drugs. The synthesis of combinatorial libraries can be performed using either insoluble or soluble polymers and also by the traditional organic synthesis in solution. Each one of these approaches presents features that may be advantageous depending on the final objective of the synthetic process. The development of high throughput screening (HTS) assays takes much time, which makes the synthesis of small and well designed combinatorial libraries the most recommended strategy.