Systemic inflammatory response syndrome in surgical patients with sepsis

Abstract

Systemic inflammatory response syndrome and sepsis are common in surgically treated patients. Systemic inflammatory response syndrome represents a major factor of morbidity and mortality in these patients. The pathogenesis of these syndromes has been increasingly clarified. The objective of this review is to present an overview of our current understanding of the physiology underlying these conditions. This article has been retracted. Link to the retraction 10.2298/SARH1206269U Sindrom sistemskog zapaljenjskog odgovora i sepsa cesta su pojava kod hirurskih bolesnika i predstavljaju jedan od glavnih faktora mortaliteta i morbiditeta u jedinicama intenzivne nege. Patogeneza ovog sindroma svakim danom biva sve jasnija, sto ce u bliskoj buducnosti verovatno dovesti i do povoljnijeg ishoda lecenja bolesnika sa ovim sindromom. Ipak, do sada primenjivani terapeutski pristupi, koji su uvedeni nakon velikih i obecavajucih studija sprovedenih kako in vitro, tako i in vivo uslovima (eksperimentalni modeli), nisu ispunili ocekivanja. Cilj ovog preglednog rada je da predstavi savremena shvatanja nastanka i tretmana sistemskog zapaljenjskog odgovora kod hirurskih bolesnika sa sepsom.