Abstract
A highly diastereoselective aldol reaction between 3-fluorooxindoles and aromatic aldehydes has been developed. Commercially available, cheap Lewis acid MgBr2[rad]OEt2 was used to promote the reaction. The reaction has a broad substrate scope with respect to both 3-fluorooxindoles and aromatic aldehydes, giving a series of α-fluoro-β-hydroxyoxindoles in good yields with high diastereoselectivities (63–94 % yield, up to 99:1 anti/syn).
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CITATION STYLE
Qiu, Z. B., Chen, L. Y., Ji, J., Ren, X., & Li, Y. (2020). Highly diastereoselective aldol reactions of 3-Fluorooxindoles promoted by MgBr2•OEt2/iPr2NEt. Journal of Fluorine Chemistry, 236. https://doi.org/10.1016/j.jfluchem.2020.109594
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