A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production

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Abstract

A facile metal-catalyzed diversification step for the synthesis of novel bi- and tricyclic scaffolds from enyne substrates is reported in this study. From a single starting material, topologically diverse scaffolds for library synthesis can be generated and decorated in a few steps. The methodology was used to produce a library of 490 compounds within the European Lead Factory (ELF) Consortium.

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Wu, P., Petersen, M. Å., Cohrt, A. E., Petersen, R., Morgentin, R., Lemoine, H., … Nielsen, T. E. (2016). A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production. Organic and Biomolecular Chemistry, 14(29), 6947–6950. https://doi.org/10.1039/c6ob01148a

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