Togni reagent: A hypervalent iodine based electrophilic trifluoromethylation reagent

Abstract

Trifluoromethylation of β-Keto Esters: Antonio Togni and co-workers have reported that β-keto esters were found to react with 3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole under phase-transfer catalysis to yield the α-trifluoromethylated derivatives.1Figure Presented. (B) Electrophilic Trifluoromethylation of Aromatic and Aliphatic Thiols: Aromatic and aliphatic thiols undergo S-trifluoromethylation in the presence of the Togni reagent 1 without formation of the corresponding disulfide. The reaction is remarkably tolerant of various functional groups and does not show significant solvent dependence. (Figure Presented). © Georg Thieme Verlag Stuttgart · New York.