Induction of Th1 cytokine responses by mycobacterial antigens in leprosy

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Abstract

Twelve mycobacterial antigens were compared for induction of gamma interferon (IFN-γ) secretion by human blood mononuclear cells of patients with leprosy. Fractionated Mycobacterium leprae antigens containing cell wall proteins or cytosolic and membrane proteins induced good IFN-γ responses in tuberculoid leprosy patients. Lipoarabinomannan from M. tuberculosis Erdman and M. leprae mycolylarabinogalactan peptidoglycan were the poorest IFN-γ inducers.

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Dockrell, H. M., Young, S. K., Britton, K., Brennan, P. J., Rivoire, B., Waters, M. F. R., … Hussain, R. (1996). Induction of Th1 cytokine responses by mycobacterial antigens in leprosy. Infection and Immunity, 64(10), 4385–4389. https://doi.org/10.1128/iai.64.10.4385-4389.1996

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