Synthesis of the schweinfurthin hexahydroxanthene core through Shi epoxidation

Abstract

Use of a Shi epoxidation for introduction of chirality in a key epoxide intermediate, together with revised protecting group tactics, has allowed an efficient synthesis of the hexahydroxanthene subunit common to the natural schweinfurthin F and the synthetic analogue 3-deoxyschweinfurthin B. © 2007 Elsevier Ltd. All rights reserved.