Peculiarities of local blood microcirculation in patients with the psoriasis

Abstract

The purpose of this work is to diagnose microcirculatory disorders in the tissues of psoriatic plaques in patients with psoriasis. Material and methods. Using the method of laser Doppler flowmetry (LDF), local hemodynamic parameters were studied in the place of psoriatic lesion of tissue and in uninvolved skin. Results. In the psoriatic plaque, there is an increase in average perfusion, myogenic and cardiac fluctuations, as well as nutritive blood flow as compared to the area of intact skin. Conclusions. The use of spectral analysis of the LDF signal has great potential for assessing the contribution of each link of the microvascular bed in the study the pathogenesis of psoriasis and evaluating the effectiveness of the therapy.