Byrsonima fagifolia niedenzu apolar compounds with antitubercular activity

Abstract

Bioassay-guided fractionation of the chloroform extract of Byrsonima fagifolia leaves led to the isolation of active antitubercular compounds alkane dotriacontane (Minimal Inhibitory ConcentrationMIC, 62.5μgmL-1), triterpenoids as bassic acid (MIC = 2.5μgmL-1), α-amyrin acetate (MIC = 62.5μgmL-1), a mixture of lupeol, α- and β-amyrin (MIC = 31.5μgmL-1) and a mixture of lupeol, and acetates of α- and β-amyrin (MIC = 31.5μgmL-1). The antimycobacterial activity was determined by the Microplate Alamar Blue Assay (MABA) and the structures of promising compounds were determined by spectroscopic analysis. This investigation constitutes the first report of a chemical and antitubercular study of apolar compounds from B. fagifolia Niedenzu (IK). Copyright © 2011 C. T. Higuchi et al.