Hyoscine butyl bromide useful in the management of perioperative bradycardia?

Abstract

Introduction: Hyoscine butyl bromide, better known as buscapine, widely used in medicine, is a muscarinic antagonist that shares properties with atropine. Objective: To review the pharmacology, mechanism of action, systemic effects, interactions, toxicity, and side effects of hyoscine butyl bromide to understand why it may be useful in the management of perioperative bradycardia. Materials and Methods: A bibliographic review was carried out in the main databases with the search of the scientific literature according to the key words defined. Conclusions: Butyl bromide hyoscine may be an option in the management of intraoperative bradyarrhythmias with a rapid onset of action, more controlled increased heart rate and low penetration to the central nervous system.