Innovative Wound Healing Strategy Through Amorphization of Active Pharmaceutical Ingredients as an Effective Approach for Hydrogel Formulation

Abstract

Amorphous solid dispersions (ASDs) provide an effective approach to overcome the poor solubility of many active pharmaceutical ingredients and can facilitate their uniform distribution within hydrogel matrices. Although ASDs are well recognized in oral formulations, their use with hydrogels for wound care remains underexplored. Hydrogels not only offer a biocompatible environment for healing wounds but also are highly versatile for 3D printing, enabling the design of patient-specific dressings customized in composition and structure. This review emphasizes the therapeutic potential of combining ASDs with hydrogel platforms, focusing on how these systems can speed up wound healing, minimize complications, and support personalized therapies. The physicochemical basis for amorphization with limitations and the synergistic effects of bioactive hydrogels are discussed to provide a conceptual basis for advancing this innovative strategy in chronic wound treatment.