Resveratrol induces a mitochondrial complex i-dependent increase in nadh oxidation responsible for sirtuin activation in liver cells

Abstract

Background: The mechanism of action of resveratrol on sirtuin and mitochondrial metabolism remains elusive. Results: Resveratrol increases the mitochondrial NAD+ level by directstimulation of complex I, leading to a SIRT3-dependent increase in substrate supplies. Conclusion: Our results link the direct stimulation by resveratrol of NADH oxidation to the SIRT3 activation. Significance: MitochondrialNAD+ NADH ratio is a critical parameter mediating resveratrol effect on mitochondrial function. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.