Cellulose-sulfuric acid as an efficient biosupported catalyst in one-pot synthesis of novel heteroaryl substituted 1,4-dihydropyridines

Abstract

An efficient method for the synthesis of new heteroaryl substituted dihydropyridine derivatives via a one-pot four-component coupling reaction of heteroaldehyde, 1,3-diketone, ethylacetoacetate, and amonium acetate in the presence of cellulose-sulfuric acid as a biosupported solid acid catalyst was developed. The reaction gave the new derivatives of fused 1,4-dihydropyridines in lower reaction times and excellent yields (85-95%). © 2013 Manouchehr Mamaghani et al.