Diagnostic accuracy of cadmium-zinc-telluridebased myocardial perfusion SPECT: Impact of attenuation correction using a co-registered external computed tomography

30Citations
Citations of this article
25Readers
Mendeley users who have this article in their library.

Abstract

Introduction Computed tomography (CT)-based attenuation correction (AC) improves the accuracy of standard myocardial perfusion SPECT. Most dedicated cadmium-zinc-telluride (CZT) SPECT cameras are not equipped with an integrated CT component.We aimed to determine the impact of AC on diagnostic performance of CZT SPECT using co-registration with an external low-dose CT. Methods Sixty patients underwent CZT SPECT (GE Discovery 530c) with 99mTc-sestamibi at rest and following regadenoson stress. Using commercial software, SPECT images were co-registered with a low-dose CT acquired on a separate system (GE Discovery 670NMCT). Attenuation corrected and non-corrected (NC) images were reconstructed using an iterative algorithm. Accuracy was measured in 44 patients who had undergone invasive angiography within 6 months. Normalcy was compared in the remaining 16 patients who had a low pre-test likelihood (,5%) of coronary artery disease (CAD). Results Summed stress and rest scores were significantly lower in AC images (9+8 vs. 13+9 and 6+7 vs. 10+9, P 0.01), while summed difference score did not differ. According to angiography, 38 patients had significant CAD in 71 vascular territories. Attenuation correction improved accuracy globally (P 0.03) and in RCA territory (P 0.008). Specificity improved both globally (100 vs. 40%, P , 0.05) and in each individual territory (LAD: 63 vs. 36%, LCX: 70 vs. 33%, RCA: 81 vs. 19%, P , 0.01). Normalcy was 100% for AC and 62.5% for NC images (P , 0.05). Conclusion Attenuation correction with a co-registered external CT is feasible using CZT cameras and improves diagnostic accuracy mostly by improving specificity over uncorrected images.

References Powered by Scopus

Incremental prognostic value of myocardial perfusion single photon emission computed tomography for the prediction of cardiac death: Differential stratification for risk of cardiac death and myocardial infarction

1100Citations
N/AReaders
Get full text

Simultaneous Transmission/Emission Myocardial Perfusion Tomography: Diagnostic Accuracy of Attenuation-Corrected <sup>99m</sup>Tc-Sestamibi Single-Photon Emission Computed Tomography

284Citations
N/AReaders
Get full text

Compared performance of high-sensitivity cameras dedicated to myocardial perfusion SPECT: A comprehensive analysis of phantom and human images

215Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Performance of cardiac cadmium-zinc-telluride gamma camera imaging in coronary artery disease: a review from the cardiovascular committee of the European Association of Nuclear Medicine (EANM)

80Citations
N/AReaders
Get full text

Solid-state detector SPECT myocardial perfusion imaging

65Citations
N/AReaders
Get full text

EANM procedural guidelines for myocardial perfusion scintigraphy using cardiac-centered gamma cameras

53Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Caobelli, F., Akin, M., Thackeray, J. T., Brunkhorst, T., Widder, J., Berding, G., … Bengel, F. M. (2016). Diagnostic accuracy of cadmium-zinc-telluridebased myocardial perfusion SPECT: Impact of attenuation correction using a co-registered external computed tomography. European Heart Journal Cardiovascular Imaging, 17(9), 1036–1043. https://doi.org/10.1093/ehjci/jev312

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 8

50%

Researcher 5

31%

Professor / Associate Prof. 2

13%

Lecturer / Post doc 1

6%

Readers' Discipline

Tooltip

Medicine and Dentistry 12

75%

Computer Science 2

13%

Pharmacology, Toxicology and Pharmaceut... 1

6%

Neuroscience 1

6%

Save time finding and organizing research with Mendeley

Sign up for free