High levels of serum interleukin-10 and tumor necrosis factor-α are associated with fatality in fulminant hepatitis

Abstract

Serum pro- and anti-inflammatory mediators in patients with acute liver diseases were assessed to clarify the clinical significance of these measurements in relation to disease severity. Concentrations of circulating tumor necrosis factor (TNF)-α, interleukin (IL)-Iβ, IL-6, IL-10, IL-12, and soluble TNF receptors (sTNFR) p55 and p75 were measured at admission in patients with fulminant hepatitis (FH; n = 19), severe acute hepatitis (AHS, n = 15), or acute hepatitis (AH, n = 7). Serum concentrations of TNF-α, IL-10, and sTNFR-55 were significantly higher in patients with FH than in those with AHS (P