Stereotactic irradiation of the resection cavity after surgical resection of brain metastases–when is the right timing?

Abstract

Purpose: This study aimed to evaluate whether an early beginning of the adjuvant stereotactic radiotherapy after macroscopic complete resection of 1–3 brain metastases is essential or whether longer intervals between surgery and radiotherapy are feasible. Material and methods: Sixty-six patients with 69 resection cavities treated with HFSRT after macroscopic complete resection of 1–3 brain metastases between 2009 and 2016 in our institution were included in this study. Overall survival, local recurrence and locoregional recurrence were evaluated depending on the time interval from surgery to the start of radiation therapy. Results: Patients that started radiotherapy within 21 days from surgery had a significantly decreased OS compared to patients treated after a longer interval from surgery (p