An efficient method for the synthesis of substituted TosMIC precursors

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Abstract

Substituted tosylmethyl isocyanides (TosMICs) are useful reagents for which no general method of preparation is available. We describe here a high-yielding method for the synthesis of substituted tosylmethyl formamides, which are readily converted to the corresponding isocyanides.

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Sisko, J., Mellinger, M., Sheldrake, P. W., & Baine, N. H. (1996). An efficient method for the synthesis of substituted TosMIC precursors. Tetrahedron Letters, 37(45), 8113–8116. https://doi.org/10.1016/0040-4039(96)01886-2

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