Two new aromadendrane sesquiterpenes from the stem Bark of Alafia multiflora

Abstract

Two new aromadendrane sesquiterpenoids (1β,4β,5α,6α,7α,11S)-aromadendr-9-en-13,14-dioic acid (1) and (1?,4?,5?,6?,7?,11S)-13-oxoaromadendr-9-en- 14-oic acid (2) have been isolated from the stem bark of Alafia multiflora along with β-sitosterol and β-sitosterol glucoside. Their structures were established on the basis of spectroscopic analyses, including 1D and 2D NMR experiments (1H-1H COSY, NOESY, HSQC, HMBC). Compound 1 showed a weak growth inhibitory activity against the murine melanoma line B16F10 MTT.