Recent trends in Cys- and Ser/Thr-based synthetic strategies for the elaboration of peptide constructs

Abstract

Recent conceptual advances in the chemical synthesis of peptide constructs are described, encompassing native chemical ligation (i.e. the chemoselective covalent condensation of unprotected peptide segments) and O-, S-acyl isopeptide strategies (i.e. internal O, S-to-N acyl transfer within peptides). © 2012 The Royal Society of Chemistry.