Toxicokinetics of NPS: Update 2017

Abstract

This summarizing and descriptive review article is an update on previously published reviews. It covers English-written and PubMed-listed review articles and original studies published between May 2016 and November 2017 on the toxicokinetics of new psychoactive substances (NPS). Compounds covered include stimulants and entactogens, synthetic cannabinoids, tryptamines, phenethylamine and phencyclidine-like drugs, benzodiazepines, and opioids. First, an overview and discussion is provided on selected review articles followed by an overview and discussion on selected original studies. Both sections are then concluded by an opinion on these latest developments. The present review shows that the NPS market is still highly dynamic and that studies regarding their toxicokinetics are necessary to understand risks associated with their consumption. Data collection and studies are encouraged to allow for detection of NPS in biological matrices in cases of acute intoxications or chronic consumption. Although some data are available, scientific papers dealing with the mechanistic reasons behind acute and chronic toxicity are still lacking.