LIPID-BASED NANOPARTICLES AS OCULAR DRUG DELIVERY SYSTEM

Abstract

Objective: Within the scope of this review, it aims to discuss the latest research on solid lipid nanoparticle (KLN) and nanostructured lipid carrier (NLT) systems for ocular use, sterilization of these formulations, and quality by design (QbD). Result and Discussion: Despite the developments in recent years, drug delivery to the eye remains a complex problem and is an area where innovative approaches are needed for effective drug delivery. This review discusses the advantages of KLNs and NLTs, innovative approaches in ophthalmic drug applications, with examples from current literature. KLNs are lipid particles prepared by melting solid lipids at room temperature or dissolving them in various solvents. NLTs, on the other hand, contain solid lipids in their structure, as well as lipids that are liquid at room temperature. One of the critical stages in ocular drug applications is the sterilization step. In choosing the appropriate sterilization process, the melting degrees, free radical formation tendencies, and particle sizes of the lipids used should be considered. In conclusion, KLNs and NLTs are promising drug delivery systems for ocular treatments in terms of biocompatibility and efficacy. The studies examined within the scope of the review also support this inference. However, it cannot be used adequately in clinical treatment due to stability problems that may be encountered during storage and difficulties in reproducible large-scale production. It is thought that QbD will be effective in solving these problems.