Hydrolysis rates of different small interfering RNAs (siRNAs) by the RNA silencing promoter complex, C3PO, determines their regulation by phospholipase Cβ

Abstract

Background: PLCβ reverses siRNA down-regulation possibly by binding to the RNA silencing promoter C3PO. Results: PLCβ binds externally to C3PO to reduce rapid hydrolysis of specific siRNAs. Conclusion: A model for PLCβ effects on C3PO-mediated siRNA hydrolysis is presented. Significance: The studies provide a clue of the genes that may be regulated by cytosolic PLCβ. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.