Artificial in vitro biosynthesis systems for the development of pseudo-natural products

Abstract

Recent advances in genome databases have allowed discov-ery of novel classes of natural products and their biosynthetic enzymes. Given the potentials and advantages of the biosyn-thetic enzymes, they are applicable to not only the production of natural products but also synthesis and discovery of artificial molecules with desired functions. This account describes our recent efforts to develop artificial in vitro biosynthesis systems that potentially allow for the elaboration of pseudo-natural peptides with novel bioactivities.