Management of Cytokine Release Syndrome (CRS) and HLH

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Abstract

Cytokine release syndrome (CRS) is caused by a rapid and mild to massive release of cytokines from immune cells involved in immune reactions, particularly after immunotherapy. The frequency and severity of CRS after CAR-T cell therapy varies between products (any grade: 37-93%, G3/4: 1-23%) (Neelapu et al. 2017; Schuster et al. 2019; Abramson et al. 2020).

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Ayuketang, F. A., & Jäger, U. (2022). Management of Cytokine Release Syndrome (CRS) and HLH. In The EBMT/EHA CAR-T Cell Handbook (pp. 135–139). Springer International Publishing. https://doi.org/10.1007/978-3-030-94353-0_26

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