Paracetamol elimination in patients with non‐insulin dependent diabetes mellitus.

Abstract

The pharmacokinetics and metabolism of an intravenous dose (500 mg) of paracetamol were studied in a group of non‐insulin dependent diabetic patients (n = 10) and in a group of healthy control subjects (n = 9). Paracetamol clearance, half‐life and the partial clearance to paracetamol glucuronide were not significantly different, but the partial clearance to paracetamol sulphate was significantly reduced (62 +/‐ 18 vs 86 +/‐ 17 ml h‐1 kg‐1 (mean +/‐ s.d.)) and the renal clearance of paracetamol was significantly increased (56 +/‐ 20 vs 22 +/‐ 6 ml h‐1 kg‐1 (mean +/‐ s.d.)) in the non‐insulin dependent diabetic patients, compared with the control group. Copyright © 1993, Wiley Blackwell. All rights reserved