Phenylketonuria with a study of the effect upon it of glutamic acid

Abstract

An account of the clinical and biochemical features of phenylketonuria is given and five cases aged only 18 months. Contrary to expectation, no alteration in blood phenylalanine was found to occur after administration of glutamic acid, though the total amount of phenylalanine and its breakdown products excreted in the urine was found to increase in all except one case. No significant increase in intelligence was found after continued administration of glutamic acid in the two patients treated.