Assessment of the changes in some diagnostic parameters in male albino rats (Rattus norvegicus) toxicated with thiodicarb insecticide

Abstract

The Present work investigates the serum levels of glucose, cholesterol, protein, urea, creatinine and some enzyme activities (AST,ALT and ALP) in male albino rats treated orally with 1/10 LD50 dose of thiodicarb insecticide (carbamate group)daily for 7 days (short-term) and 30days (long-term). A highly significant elevation in serum urea, creatinine, AST and ALT accompanied by a highly significant decrease in the body weight and a significant increase in serum glucose level were recorded in rats of long-term group. While, the short-term group showed a highly significant increase in serum level of glucose and urea. Moreover, a significant decrease in serum cholesterol content was recorded but the total protein concentration and ALP activity were not affected.