Synthesis, Characterization and Pharmacological Screening of Some Substituted 1,2,3- & 1,2,4-Triazoles

Abstract

The triazole nucleus is an important part of the therapeutically interesting drug candidate as antimicrobial, analgesic, anticancer, anticonvulsant and anti-inflammatory agents. Therefore, a number of 1,2,3- & 1,2,4-triazole deriva- tives were synthesized. The structures of these compounds were characterized by means of FT-IR, 1H-NMR, and elemental analysis. All the compounds were evaluated for antimicrobial activity, using Kirby-Bauer disk diffusion method and anti-inflammatory activity, using carrageenan-induced acute paw oedema method. Some of the compounds exhibited en- couraging antimicrobial and anti-inflammatory results when compared with standard drugs.