Association of early-stage incidence and mortality in malignant melanoma – a population-based ecological study

Abstract

Background: Germany-wide skin cancer screening was introduced in 2008 to reduce skin cancer mortality and morbidity. However, the effectiveness of the program is still unclear. We explore the relationship between early-stage melanoma incidence and melanoma mortality in subsequent years, using early-stage melanoma incidence as surrogate for screening participation and early detection. Patients and Methods: Data on melanoma incidence for 2005–2016 and melanoma mortality for 2005–2018 were obtained for 244 German counties. We investigated the correlation between several measures of incidence and mortality with correlation analyses and linear regressions. Results: Melanoma incidence of early stages (in situ and T1) rose by 69% between pre-screening (2005–2007) and screening period (2008–2010). In contrast, there was no temporal trend in mortality over time. Correlation coefficients between incidence and mortality variables ranged between –0.14 and 0.10 (not significant). Linear regression indicated that mortality 6 years after screening introduction decreases with increasing change in early-stage incidence (b = –0.0029, 95% confidence interval [–0.0066, 0.0007]). Conclusions: The estimated population-based effects of skin cancer screening on melanoma mortality were minimal and not significant. A potential effectiveness cannot be demonstrated.