The multifaceted nature of nucleobindin‐2 in carcinogenesis

Abstract

Nucb2 is a multifunctional protein associated with a variety of biological processes. Multiple studies have revealed that Nucb2, and its derivative nesfatin‐1, are involved in carcinogenesis. Interestingly, the role of Nucb2/nesfatin‐1 in tumorigenesis seems to be dual—both pro‐metastatic and anti‐metastatic. The implication of Nucb2/nesfatin‐1 in carcinogenesis seems to be tissue de-pendent. Herein, we review the role of Nucb2/nesfatin‐1 in both carcinogenesis and the apoptosis process, and we also highlight the multifaceted nature of Nucb2/nesfatin‐1.