Novel fluorescent isoquinoline derivatives obtained via Buchwald-Hartwig coupling of isoquinolin-3-amines

Abstract

Isoquinolin-3-amines bearing an alkyl group or hydrogen atom in position 4 easily underwent Buchwald-Hartwig coupling reactions with various substituted aryl halides. Investigation of the selected new derivatives with fluorescent spectroscopy revealed that the reaction products have similar photophysical properties to those of isoquinolin-3-amine except the N-(nitrophenyl) derivatives, which emit negligible fluorescence.