A practical synthesis of chiral 3-aryloxy-1,2-propanediols

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Abstract

Chiral 3-aryloxy-1,2-propanediols (1-5) of >96% ee were obtained in high yield by the nucleophilic addition of substituted phenols to chiral glycidol in the presence of piperidine hydrochloride as catalyst.

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Karakaplan, M., Turgut, Y., & Hoşgören, H. (2005). A practical synthesis of chiral 3-aryloxy-1,2-propanediols. Journal of Chemical Research, (1), 41–42. https://doi.org/10.3184/0308234053431112

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