TINTIN, at the interface of chromatin, transcription elongation, and mRNA processing

Abstract

Recent work including high-resolution genome-wide analysis uncovered a new trimeric complex involved in transcription elongation, both as an integral part of the NuA4 histone acetyltransferase and as an independent functional entity. The complex is conserved in eukaryotes and is named TINTIN, for Trimer Independent of NuA4 for transcription Interactions with Nucleosomes. This point of view covers the current knowledge regarding TINTIN’s function in modulating chromatin structure and influencing transcription elongation in eukaryotes. It also points to several physical and functional links to co-transcriptional processes, including interactions with the mRNA splicing machinery and the nuclear exosome.