Electrochemical oxidative N-H/P-H crosscoupling with H2 evolution towards the synthesis of tertiary phosphines

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Abstract

Tertiary phosphines(iii) find widespread use in many aspects of synthetic organic chemistry. Herein, we developed a facile and novel electrochemical oxidative N-H/P-H cross-coupling method, leading to a series of expected tertiary phosphines(iii) under mild conditions with excellent yields. It is worth noting that this electrochemical protocol features very good reaction selectivity, where only a 1: 1 ratio of amine and phosphine was required in the reaction. Moreover, this electrochemical protocol proved to be practical and scalable. Mechanistic insights suggested that the P radical was involved in this reaction.

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Yuan, Y., Liu, X., Hu, J., Wang, P., Wang, S., Alhumade, H., & Lei, A. (2022). Electrochemical oxidative N-H/P-H crosscoupling with H2 evolution towards the synthesis of tertiary phosphines. Chemical Science, 13(10), 3002–3008. https://doi.org/10.1039/d1sc07248j

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