E1(k), another quantitative variant at cholinesterase locus I

Abstract

Two families segregating for the atypical (E(1a)) allele at cholinesterase locus 1 are described. Unusual results for dibucaine inhibition led to the recognition of a new allele (E(1k)) also segregating in these families. The enzymatic and immunological data are consistent with the hypothesis that E(1k) causes reduction of 'usual' (E(1u)) molecules by about 33%. Whether the reduction of E(1u) caused by E(1k) is caused by retarded synthesis or accelerated degradation of serum cholinesterase remains to be determined.