Management of Anticoagulation Therapy in Patients with Thromboembolism in the Context of Renal Dysfunction: Challenging Cases and Practical Algorithms

Abstract

Background: Low-molecular-weight heparin is cleared through the kidneys and is commonly used for anticoagulation in the pediatric population. Observation: We present 3 challenging cases of children requiring anticoagulation in the context of acute kidney injury, nephrotic syndrome, and hemodialysis. Conclusions: A significant change in anti-factor Xa (anti-Xa) levels - used for drug monitoring - should prompt an assessment of renal function. In nephrotic syndrome, anti-Xa levels should be closely monitored when there is a change in the status of nephrotic disease activity. In hemodialysis patients, enoxaparin at once daily reduced dosing should be considered with trough and peak anti-Xa levels monitoring.