Free radical-scavenging potential of methanol extracts of Solanum surattense

Abstract

Natural products from plants provide unlimited opportunities for discovery of new drugs. The present study was aimed to evaluate the total phenolic content, total flavonoids content and their influence on different antioxidant activities. The antioxidant activity was evaluated by Ferric Reducing Ability of Plasma (FRAP), peroxidase assay, ABTS (2, 2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium) and lipid peroxidation assay (LPO). The maximum total phenolic and flavonoids content was observed in leaves, 25.91±0.8035 mg GAE/g DW and 17.7±2.36 mg QE/g DW, respectively. Fruits showed the maximum ABTS activity (IC50 = 53.97±5.64 mM L-1 g-1) while leaves showed maximum peroxidase (0.472±0.02 mM mm-1 g-1 DW), LPO activity (36.21±4.21 MDA g-1 DW). The ethyl acetate extract of leaves showed maximum FRAP activity in leaves (529.67±5.5 mM L-1 g-1 DW) compared to methanol and hexane extracts. These results clearly indicate that S. surattense is effective against free radical mediated diseases. © 2014 Academic Journals Inc.