Antimicrobial activity of the novel metal oxide nanoparticles against selected human pathogenic bacteria

Abstract

Antibacterial activities of the selected metal oxide nanoparticles viz., lead oxide (PbO), silver oxide (Ag2O), tin oxide (SnO2), alpha manganese sesquioxide (α-Mn2O3), cerium oxide (CeO2), silver doped tin oxide (Ag-SnO2), silver doped alpha manganese sesquioxide (Ag-α-Mn2O3), silver doped lead oxide (Ag-PbO) and silver doped cerium oxide (Ag-CeO2) have been successfully investigated against human pathogens, viz., Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Proteus mirabilis. The antibacterial studies of the selected nanoparticles are primarily investigated by the well diffusion process. Different concentrations of the nanoparticles are analyzed by the minimal inhibitory concentration (MIC) technique. Among the metal oxide nanoparticles, the Ag-doped CeO2 nanoparticles showed maximum inhibition against E.coli, followed by against P. aeruginosa, P. mirabilis and K. pneumoniae. Further, the MIC studies showed that, the Ag-CeO2 nanoparticles exhibited maximum inhibition against human pathogenic bacteria.