Antibody uptake into neurons occurs primarily via clathrin-dependent Fcα receptor endocytosis and is a prerequisite for acute tau protein clearance

Abstract

Background: How Tau immunotherapy clears Tau is not well known. Results: Tau antibody uptake correlates with Tau levels, is primarily via clathrin-dependent FcII/III endocytosis, and is required for acute Tau clearance. Conclusion: Following receptor-mediated uptake into neurons, antibodies co-localize with Tau aggregates and promote Tau clearance. Significance: Results support intracellular clearance as a viable route for immunotherapy and have major implications for future development. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.