963 Pregnancy-Associated Plasma Protein a Levels and Neonatal Complications in Post-Term Pregnancies

Abstract

Objectives To assess the association between serum pregnancy-associated plasma protein A (PAPP-A) measured in the first trimes-ter and perinatal complications in post-term pregnancies. Methods A total of 4948 singleton pregnant women, who deliv-ered after 40 +0 gestational weeks, were included at Aarhus Univer-sity Hospital between January 2005 and December 2007. Serum levels of PAPP-A were determined at the first-trimester screening for Down syndrome (GA 8 +0 – 13 +6). Labor was not induced routinely until 42 +0 weeks of gestation. However, in women with diabetes mellitus, gestational diabetes, preeclampsia, hypertension, prelabor rupture of membranes, twin pregnancies, fetal growth restriction and intrahepatic cholestasis, labor were induced by 40 completed weeks or earlier and were not included in the study. Results In post-term pregnancies first-trimester serum PAPP-A below 0.4 MoM was associated with small weight for gestation (< 5 th