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Microwave-promoted synthesis of β-hydroxyesters by the Reformatsky reaction in the absence of solvent

Journal of Chemical Research - Part S (2003) (6) 374-376
DOI: 10.3184/030823403103174209
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Abstract

A microwave-promoted Reformatsky reaction of aldehydes and ketones with ethyl bromoacetate, in the absence of solvent, using activated zinc metal and solid NH4Cl afforded the corresponding β-hydroxyesters in good to excellent yields.

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Gholap, A. R., & Chavan, A. P. (2003). Microwave-promoted synthesis of β-hydroxyesters by the Reformatsky reaction in the absence of solvent. Journal of Chemical Research - Part S, (6), 374–376. https://doi.org/10.3184/030823403103174209

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