Structural characterization of a polysaccharide from gastrodia elata and its bioactivity on gut microbiota

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Abstract

A novel homogeneous polysaccharide named GEP-1 was isolated and purified from Gastrodia elata (G. elata) by hot-water extraction, ethanol precipitation, and membrane separator. GEP-1, which has a molecular weight of 20.1 kDa, contains a polysaccharide framework comprised of only glucose. Methylation and NMR analysis showed that GEP-1 contained 1,3,6-linked-α-Glcp, 1,4-linked-α-Glcp, 1,4-linked-β-Glcp and 1,4,6-linked-α-Glcp. Interestingly, GEP-1 contained citric acid and repeating p-hydroxybenzyl alcohol as one branch. Furthermore, a bioactivity test showed that GEP-1 could significantly promote the growth of Akkermansia muciniphila (A. muciniphila) and Lacticaseibacillus paracasei (L. paracasei) strains. These results implied that GEP-1 might be useful for human by modulating gut microbiota.

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Huo, J., Lei, M., Li, F., Hou, J., Zhang, Z., Long, H., … Wu, W. (2021). Structural characterization of a polysaccharide from gastrodia elata and its bioactivity on gut microbiota. Molecules, 26(15). https://doi.org/10.3390/molecules26154443

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